The Role of NF-κB Inhibitors in Cell Response to Radiation

Author(s): Sajjad Molavi Pordanjani, Seyed Jalal Hosseinimehr

Journal Name: Current Medicinal Chemistry

Volume 23 , Issue 34 , 2016

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Abstract:

It is well documented that ionizing radiation (IR) activates the transcription factor (NF-κB) which is a trigger for resistance cancer cells to treatment. It is involved in activation of pro-survival signaling pathways and resulting in cancer development and progression. In unstimulated condition, NF-κB is sequestered in cytoplasm but after the cell exposure to IR, proteasomal degradation of IκB flowing phosphorylation via IKK, leads to aberrantly NF-κB activation and nuclear translocation. Therefore, interruption in IκB degradation, proteasome action, IKK phosphorylation and NF-κB nuclear translocation provide robust strategies for inhibiting adverse effect of IR induced NF-κB. In spite of uncompleted elucidation of NF-κB molecular mechanisms, different NF-κB inhibitors have been used in order to inhibiting the IR induced NF-κB. The aim of this review is to highlight the role of IR induced-NF-κB inhibitors such as MG132, bortezomib, curcumin, DHMEQ, naringin, sorafenib, genistein and parthenolide in suppression of IR induced NF-κB adverse effects. Moreover, their chemical, structural characteristics and molecular mechanisms will be discussed.

Keywords: Transcription factor, tumor, radiosensitizing, radioprotective, radiation, NF-κB inhibitors.

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Article Details

VOLUME: 23
ISSUE: 34
Year: 2016
Published on: 03 November, 2016
Page: [3951 - 3963]
Pages: 13
DOI: 10.2174/0929867323666160824162718
Price: $65

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