Background: Protein farnesyltransferase (PFT) inhibitors have emerged as a potent target
for the malaria treatment caused by the Plasmodium falciparum (Pf) parasite.
Objective: To explore the various scaffolds which are active against Pf-PFT target.
Result: Seven inhibitor scaffolds based on ethylenediamine, peptidomimetic, benzophenone, benzamide,
tetrahydroquinoline, naphthyridine and oxy-tetrahydroquinoline, have been developed till date.
Conclusion: It is concluded that naphthyridine based drugs are the most promising one. Furthermore,
introducing the hydrophobic molecules like isoprenyl groups to a protein or a chemical compound facilitate
protein-protein and protein-membrane interactions thereby makes them good candidates as
new therapeutics. The future research should focus on the disease rather than the infection and the dynamics
of its transmission; this will bring a new vision about the disease.