Background: Beta-blockers reduce mortality in chronic heart failure.
Objectives: To study intra-hospital mortality and adverse cardiovascular (CV) outcomes in relation to
beta-blockade therapy in acute decompensated heart failure.
Methods: We retrospectively analyzed a 22-year registry of acute decompensated heart failure (ADHF) in
the Middle East.
Results: Out of the total 8066 patients admitted for ADHF, 1242(15.4%) were on beta-blockers on admission.
Among those, beta-blockers were discontinued in 26.5%. Despite the existence of less CV comorbidities
in patients not treated by beta-blockers, in-hospital mortality and stroke/transient ischemic attacks
rates were higher in those patients compared with patients on beta-blockers on admission (14.4 vs. 3.6%,
p=0.001, 0.6 vs. 0.1%, p=0.02; respectively). Additionally, continuation of beta-blockers during acute
decompensation was associated with less mortality risk (p=0.001). The use of beta-blockers on admission
and discharge increased significantly with time whereas in-hospital mortality decreased (p=0.001). Nevertheless,
admission year was not a predictor of reduced mortality in patients treated with beta-blockers on
admission (OR 0.93, 95% CI [0.56-1.54], p=0.77).
Conclusion: Previous beta-blockade therapy in patients presenting with ADHF decreases intra-hospital
mortality and the incidence of CV events and stroke/transient ischemic attacks. Moreover, nonwithdrawal
of beta-blockers during hospitalization has a favorable outcome.