New Page to Access Pyrazines and their Ring Fused Analogues: Synthesis from N-Propargylamines

Author(s): Esmail Vessally*, Akram Hosseinian, Ladan Edjlali, Ahmadreza Bekhradnia*, Mehdi D. Esrafili

Journal Name: Current Organic Synthesis

Volume 14 , Issue 4 , 2017

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


The development of efficient routes to pyrazines and their ring fused analogues is an attractive area of research since these compounds are now widely recognized as important N-heterocycles for their potential use in medicinal and agricultural scientific fields. In this review, we describe the most representative and interesting methods for the synthesis of pyrazines from N-propargylamines. Mechanistic aspects of the reactions are considered and discussed in detail.

Keywords: Pyrazines, ring fused pyrazines, N-propargylamines, 6-exo-dig cyclization, 1, 3-dipolar cycloaddition.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2017
Published on: 18 August, 2016
Page: [557 - 567]
Pages: 11
DOI: 10.2174/1570179413666160818144816
Price: $65

Article Metrics

PDF: 25