Background: The rheumatologic manifestations of hematologic neoplasms are a collection
of diverse syndromes. This review aims to describe the most common syndromes in the context
of potential mechanisms of pathogenesis.
Methods: We undertook a structured search of the available peer-reviewed literature describing
paraneoplastic phenomena associated with hematologic neoplasms and the most current literature on
the biology of inflammation and neoplasm.
Results: This review describes the common rheumatologic manifestations and discusses their possible
Conclusions: This review describes common clinical features of paraneoplastic phenomena prevalent
in hematologic malignancies that may help differentiate them from primary rheumatologic disease
and discusses the most current understanding of underlying pathogenesis with a specific focus
on the biology of inflammation in neoplastic transformation.