Title:Remote Neural Stimulation Using Magnetic Nanoparticles
VOLUME: 24 ISSUE: 5
Author(s):Andy Tay and Dino Di Carlo
Affiliation:Department of Bioengineering, University of California, Los Angeles, CA 90095, Department of Bioengineering, University of California, Los Angeles, CA 90095
Keywords:Mechanotranduction, magnetotactic bacteria, ferritin, TRPV1, blood brain barrier, thermogenetics,
magnetogenetics, mechanosensitive ion channels.
Abstract:Neural stimulation provides a means for scientists to investigate brain functions
and neurological diseases. There is also mounting interest in using remote stimulation of neuronal
circuits for brain-machine interfaces. In this review, we highlight recently developed
technologies utilizing magnetic nanoparticles to generate heat or exert mechanical forces for
remote control of brain circuits and compare these with conventional (electrical stimulation
and drugs) and second-generation (ultrasound and light) techniques. We also present some of
the challenges and progress in areas like genetics, nanoparticle synthesis and energy delivery
devices to translate the use of these innovative nanoparticle-based platforms in research and
clinical settings.
