Paracoccidioides brasiliensis and P. lutzii cause human paracoccidioidomycosis (PCM).
They are dimorphic ascomycetes that grow as filaments at mild temperatures up to 28oC and as
multibudding pathogenic yeast cells at 37oC. Components of the fungal cell wall have an important
role in the interaction with the host because they compose the cell outermost layer. The Paracoccidioides
cell wall is composed mainly of polysaccharides, but it also contains proportionally smaller
rates of proteins, lipids, and melanin. The polysaccharide cell wall composition and structure of
Paracoccidioides yeast cells, filamentous and transition phases were studied in detail in the past.
Other cell wall components have been better analyzed in the last decades. The present work gives to
the readers a detailed updated view of cell wall-associated proteins. Proteins that have been localized
at the cell wall compartment using antibodies are individually addressed. We also make an overview
about PCM, the Paracoccidioides cell wall structure, secretion mechanisms, and fungal extracellular
Keywords: Paracoccidioides, cell wall, proteins, secretion, dmorphie, lipids, melanin.
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