Potential Linkage Between Cerebrovascular Diseases and Metabolic Syndrome

Author(s): Nasimudeen R. Jabir, Chelapram Kandy Firoz, Mohd. Shahnawaz Khan, Syed Kashif Zaidi, Ghulam Md. Ashraf, Shazi Shakil, Mohammad Amjad Kamal, Shams Tabrez

Journal Name: Current Drug Metabolism

Volume 18 , Issue 1 , 2017

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Graphical Abstract:


Cerebrovascular disease (CD) and metabolic syndrome (MetS) are two devastating health dilemma that continues to be a potential contributor to disability and mortality in human population all across the world. Scientific data clearly shows several mechanistic similarities between these two co-existing and interlinked conditions. The linkage exacerbates ongoing patho-physiological condition towards more lethal events. In view of the presence of modifiable risk factors in both CD and MetS, their management holds potential therapeutic value. Hence, developing common treatment strategies for these diseases could involve common molecular agents. In this communication, we have summarized some of the common pathological conditions viz. abdominal obesity, insulin resistance, dyslipidemia, hypertension, and endothelial dysfunction that further deteriorate existing homeostasis in CD and MetS. Based on our article, it is advocated that substantial improvements in novel multi-targeted drug discovery could provide the effective treatment methods in order to avoid the fatal complications related with CD and MetS.

Keywords: Cerebrovascular disease, dislipidemia, endothelial dysfunction, hypertension, insulin resistance, metabolic syndrome, obesity.

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Article Details

Year: 2017
Published on: 18 January, 2017
Page: [62 - 68]
Pages: 7
DOI: 10.2174/1389200217666160810155055
Price: $65

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