Cerebrovascular disease (CD) and metabolic syndrome (MetS) are two devastating health dilemma that
continues to be a potential contributor to disability and mortality in human population all across the world. Scientific
data clearly shows several mechanistic similarities between these two co-existing and interlinked conditions. The linkage
exacerbates ongoing patho-physiological condition towards more lethal events. In view of the presence of modifiable
risk factors in both CD and MetS, their management holds potential therapeutic value. Hence, developing common
treatment strategies for these diseases could involve common molecular agents. In this communication, we have
summarized some of the common pathological conditions viz. abdominal obesity, insulin resistance, dyslipidemia,
hypertension, and endothelial dysfunction that further deteriorate existing homeostasis in CD and MetS. Based on our
article, it is advocated that substantial improvements in novel multi-targeted drug discovery could provide the effective
treatment methods in order to avoid the fatal complications related with CD and MetS.
Keywords: Cerebrovascular disease, dislipidemia, endothelial dysfunction, hypertension, insulin resistance, metabolic syndrome, obesity.
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