Title:Investigations of Malignant Mesothelioma
VOLUME: 12 ISSUE: 3
Author(s):Jack A. Kastelik, Mahmoud Loubani, Gerard Avery, Anthony G. Arnold and Jaymin Morjaria
Affiliation:Department of Respiratory Medicine, Hull University, Hull York Medical School, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK.
Keywords:Investigations, malignant mesothelioma, radiology.
Abstract:Malignant mesothelioma is an aggressive form of cancer affecting the pleura and the serous
membranes. Asbestos exposure has been shown to be the most important factor contributing to the
development of malignant mesothelioma. The current guidelines suggest that investigations and
management of patients with mesothelioma require multidisciplinary teamwork, which allows for
imple-mentation of structured diagnostic algorithms resulting in more efficient and timely diagnosis
and implementation of therapeutic strategies. Majority of patients with malignant mesothelioma
present with pleural effusion. Therefore imaging including thoracic ultrasound, computed tomography
and Positron Emission Tomography form an important part of investigations. However, in the context
of malignant mesothelioma each of these imaging modalities has its limitations. For this reason,
invasive procedures such as thoracocentesis, medical or surgical thoracoscopy remain important tools
for obtaining histological diagnosis of malignant mesothelioma. In this review, we will discuss
investigational approaches applied in diagnosing malignant mesothelioma.
