This mini-review article provides an overview on the use of magnetic materials
for the analysis of protein biomarkers. In particular, the advantage provided by magnetic
solid phase extraction will be discussed with selected examples, considering untargeted
analysis for screening new biomarker proteins and targeted investigation on known and suggested
new biomarkers. Aspects, such as enrichment efficiency over conventional techniques,
ease of use, functionalization versatility and automation will be considered, together
with quantification and deeper structure elucidation provided by coupling selective or specific
enrichment to powerful characterization techniques, such as mass spectrometry.