Organocatalysis is an emerging and new field towards the direction of asymmetric
synthesis and has shown a tremendous growth in 21st century. As the demand for chiral
pharmaceuticals and chiral organic molecules is increasing immensely, different types of organocatalysts
have been developed and used from time to time. The cinchona alkaloids and
amino acid proline were the first organocatalysts used in this area followed by incredible
growth in the form of urea/thiourea, DMAP, proline derivatives, squaramides, peptides, etc.
The squaramide based organocatalysts are gaining impetus for asymmetric transformations
and have shown remarkably good results in diverse type of reactions, wherein they usually
act as linkers between two privileged skeletons. Due to its unique structural feature and wide
application, squaramide holds a prominent and great potential in asymmetric synthesis. The
present mini-review will briefly cover the squaramide based organocatalysts and the examples
of organic reactions catalyzed by them.