Background: Non-small cell lung cancer is the leading cancer-related
cause of death.
Objective: We review the latest therapies for NSCLC with EGFR and ELM4-ALK
mutations as well as the most relevant studies and promising patents.
Method: A literature search of PubMed database was carried out to identify recent
Clinical Trials using EGFR therapies and novel patents involving diagnosis and therapies
on NSCLC. We conducted a search to find new therapy strategies, new biomarkers,
and selected five patents we find relevant.
Results: Over the last few years, identification of cancer harboring epidermal growth
factor receptor mutations (EGFR) or chromosomal rearrangements of anaplastic lymphoma kinase (ALK)
led to new ways in classifying and treating NSCLC. On the other hand, acquired resistance are a constantly
challenge in the management of patients with these mutations and new drugs options are in development
to improve and amplify treatment strategies.
Conclusions: Currently, EGFR TKIs (e.g.: erlotinib, gefitinib, osimertinib) and ALK inhibitors (crizotinib,
ceritinib, alectinib) provided a new face for advanced NSCLC outcomes. To understand the disease
molecular profile is mandatory to define the best approach for each patient.