Antidotal Effects of Curcumin Against Agents-Induced Cardiovascular Toxicity

Author(s): Tahereh Farkhondeh, Saeed Samarghandian

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
Formerly Current Drug Targets - Cardiovascular & Hematological Disorders

Volume 16 , Issue 1 , 2016

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Graphical Abstract:


Curcumin, the major phenolic compound in turmeric, shows preventive effects in various diseases. Curcumin is commonly found in rhizome of the Curcuma species and traditionally used in herbal medicine. Numeros studies has indicated that curcumin posses protective effects against toxic agents in various systems including cardiovascular. This study found that curcumin may be effective in cardiovascular diseases induced by toxic agents including Streptozotocin, Doxorubicin, Cyclosporin A, Methotrexate, Isoproterenol, Cadmium, Diesel exhaust particle, Nicotine, Hydrogen peroxide, and tert- Butyl hydroperoxide. However, due to the lake of information on human, further studies are needed to determine the efficacy of curcumin as an antidote agent. The present study aimed to critically review the recent literature data from that regarding the protective effects of curcumin against agents-induced cardiovascular toxicity.

Keywords: Antioxidant, cardiovascular, curcumin, toxic agents.

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Article Details

Year: 2016
Published on: 20 October, 2016
Page: [30 - 37]
Pages: 8
DOI: 10.2174/1871529X16666160802144510

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