Abnormal Peri-Organ or Intra-organ Fat (APIFat) Deposition: An Underestimated Predictor of Vascular Risk?

Author(s): Niki Katsiki, Vasilios G. Athyros, Dimitri P. Mikhailidis

Journal Name: Current Vascular Pharmacology

Volume 14 , Issue 5 , 2016

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Adipose tissue, a major endocrine organ, consists of brown and white adipocytes. Brown fat may play a beneficial role in cardiometabolic disorders. Brown adipose tissue can also improve glucose and lipid metabolism. In contrast, the expansion of white adipose tissue has been related to obesity, type 2 diabetes mellitus and cardiovascular disease (CVD). Both the quantity and the quality of the white adipose tissue as well as its distribution may affect CVD risk. In this context, the link between adiposity and CVD risk is greater for visceral than subcutaneous fat. Apart from these fat depots, there are other adipose tissues that are either systemically (i.e. in the liver, muscle or neck) or mainly locally acting (i.e. pericardial/epicardial, perivascular and perirenal). These fat depots can affect the nearby anatomic organs via lipid accumulation and cytokine secretion.

In the present narrative review, the associations of excessive peri-organ adipose tissue, namely intrahepatic, epicardial/ pericardial, perivascular, intramuscular, peripancreatic and perirenal fat, with cardiometabolic and CVD risk factors are discussed. The effects of drugs that target vascular risk and/or different fat depots are also considered.

Keywords: Non-alcoholic fatty liver disease, epicardial fat, perivascular, intramuscular fat, perirenal fat, peripancreatic fat, vascular risk.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2016
Published on: 22 July, 2016
Page: [432 - 441]
Pages: 10
DOI: 10.2174/1570161114666160722112738
Price: $65

Article Metrics

PDF: 43
PRC: 1