Abstract
Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment. Curcumin, the most active component of rhizome of Curcuma longa L. (common name: turmeric), has been studied for many years due to its bio-functional properties, especially antioxidant, radical scavenger, antimicrobial and anti-inflammatory activities, which play a crucial role in the wound healing process. Moreover, curcumin stimulated the production of the growth factors involved in the wound healing process, and so curcumin also accelerated the management of wound restoration. The aim of the present review is collecting and evaluating the literature data regarding curcumin properties potentially relevant for wound healing. Moreover, the investigations on the wound healing effects of curcumin are reported. In order to produce a more complete picture, the chemistry and sources of curcumin are also discussed.
Keywords: Antioxidant, anti-inflammatory, curcumin, polyphenol, wound healing.
Current Pharmaceutical Biotechnology
Title:Wound Healing Effects of Curcumin: A Short Review
Volume: 17 Issue: 11
Author(s): Silvia Tejada, Azadeh Manayi, Maria Daglia, Seyed F. Nabavi, Antoni Sureda, Zohreh Hajheydari, Olga Gortzi, Hamidreza Pazoki-Toroudi and Seyed M. Nabavi
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Keywords: Antioxidant, anti-inflammatory, curcumin, polyphenol, wound healing.
Abstract: Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment. Curcumin, the most active component of rhizome of Curcuma longa L. (common name: turmeric), has been studied for many years due to its bio-functional properties, especially antioxidant, radical scavenger, antimicrobial and anti-inflammatory activities, which play a crucial role in the wound healing process. Moreover, curcumin stimulated the production of the growth factors involved in the wound healing process, and so curcumin also accelerated the management of wound restoration. The aim of the present review is collecting and evaluating the literature data regarding curcumin properties potentially relevant for wound healing. Moreover, the investigations on the wound healing effects of curcumin are reported. In order to produce a more complete picture, the chemistry and sources of curcumin are also discussed.
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Tejada Silvia, Manayi Azadeh, Daglia Maria, Nabavi F. Seyed, Sureda Antoni, Hajheydari Zohreh, Gortzi Olga, Pazoki-Toroudi Hamidreza and Nabavi M. Seyed, Wound Healing Effects of Curcumin: A Short Review, Current Pharmaceutical Biotechnology 2016; 17 (11) . https://dx.doi.org/10.2174/1389201017666160721123109
DOI https://dx.doi.org/10.2174/1389201017666160721123109 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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