Increased Exercise Favorably Modifies Coronary Artery Disease and Peripheral Arterial Disease Outcomes

Author(s): Thomas F. Whayne, Debabrata Mukherjee

Journal Name: Current Vascular Pharmacology

Volume 14 , Issue 5 , 2016

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Exercise therapy, especially when supervised on-site in a clinical facility or directed off-site for a home-based program, is an essential component of the management of coronary artery disease (CAD) and peripheral arterial disease (PAD). In the case of both atherosclerotic diseases, it can decrease adverse cardiovascular (CV) events. There has been a recent push toward invasive management of both CAD and PAD but accumulating clinical experience has shown the limitation of invasive management and emphasized the importance of medications, CV risk reduction, conditioning, and exercise, especially when supervised. Exercise results in increased peak oxygen consumption (V02), improvement of wellestablished CV risk factors such as plasma lipids, and an improvement in indicators of inflammation and of various metabolic factors. Fortunately, there is generally good third-party coverage of medications and vascular interventions but unfortunately, poor insurance coverage for supervised or directed exercise programs for which significant patient benefit has been established.

Keywords: Cardiovascular risk reduction, claudication, coronary artery disease, exercise training, low-density lipoprotein cholesterol, major adverse cardiac event, peripheral arterial disease, secondary prevention.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2016
Published on: 05 October, 2016
Page: [458 - 465]
Pages: 8
DOI: 10.2174/1570161114999160719104936
Price: $65

Article Metrics

PDF: 30
PRC: 1