Title:RNAi-Based Therapy in Experimental Ischemia-Reperfusion Injury. The New Targets
VOLUME: 22 ISSUE: 30
Author(s):Laura de Ramon, Marta Jarque, Elia Ripoll, Oriol Bestard, Josep M. Grinyo and Juan Torras
Affiliation:xperimental Nephrology, Departament de Ciències Clíniques, Universitat de Barcelona, Institut d’investigació biomedica de Bellvitge (IDIBELL), Hospitalet Llobregat, Barcelona, Spain.
Keywords:Ischemia, siRNA, gene silencing, CD40.
Abstract:Background: Ischemia reperfusion injury is an important pathophysiological
process in many fields such as transplantation, stroke, atherosclerosis, trauma and myocardial
infarction. Recent advances in gene silencing may help to reduce ischemic effects, targeting
molecules related to this pathological process. Methods and results: Here, we review
the different silencing approaches in ischemic injury, highlighting the role of co-stimulatory
molecules in renal transplantation. Conclusion: Gene silencing appears as a new strategy to
prevent the inflammation and injury associated with ischemia.
