A Review on Structures and Functions of Bcl-2 Family Proteins from Homo sapiens

Author(s): Dakshinamurthy Sivakumar, Thirunavukkarasu Sivaraman

Journal Name: Protein & Peptide Letters

Volume 23 , Issue 10 , 2016


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Abstract:

Cancer cells evade apoptosis, which is regulated by proteins of Bcl-2 family in the intrinsic pathways. Numerous experimental three-dimensional (3D) structures of the apoptotic proteins and the proteins bound with small chemical molecules/peptides/proteins have been reported in the literature. In this review article, the 3D structures of the Bcl-2 family proteins from Homo sapiens and as well complex structures of the anti-apoptotic proteins bound with small molecular inhibitors reported in the literature to date have been comprehensively listed out and described in detail. Moreover, the molecular mechanisms by which the Bcl-2 family proteins modulate the apoptotic processes and strategies for designing antagonists to anti-apoptotic proteins have been concisely discussed.

Keywords: Apoptosis, Bcl-2 family proteins, anti-cancer compounds and structure-function relationships.

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Article Details

VOLUME: 23
ISSUE: 10
Year: 2016
Published on: 21 September, 2016
Page: [932 - 941]
Pages: 10
DOI: 10.2174/0929866523666160719094636
Price: $65

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