Abstract
The emergence of bacterial resistance to conventional antibiotics has been become a major issue in the health system. Currently, studies are being performed to develop new drugs that can replace conventional antibiotics. These new drugs include the antimicrobial peptides (AMPs), a heterogeneous group of molecules produced in a variety of bacterial, invertebrate, plant and animal species, which can serve as a nonspecific defense system that complements the highly specific cell-mediated immune response. AMPs have antimicrobial activities against a wide range of microorganisms, including bacteria, fungi, and viruses, and they are effective against pathogenic organisms that are resistant to common drugs. The most common mechanism of action of antibacterial peptides on microbial cells has been characterized as an alteration in the cellular membrane permeability. In contrast, there are AMPs with unusual strategies associated with cell wall and protein synthesis inhibition, nucleic acid binding or inactivation of toxins that enable microbial infection. Many pathogens can develop resistance strategies, inactivating or repelling AMPs through modification of the surface expression of pumps or secretion of proteases. In summary, this review focus on AMPs with non-conventional modes of actions and the microbial counter measures to resist these peptides.
Keywords: Antimicrobial activity, Toxin, Disease control, Mechanism of action, Peptides, Unusual activity.
Current Topics in Medicinal Chemistry
Title:Elucidating Unusual Modes of Action and Resistance of Antibacterial Peptides
Volume: 17 Issue: 5
Author(s): Leandro dos Santos Machado, Esther Vilas Boas de Carvalho, Flávia Varela de Affonseca e Silva, Pedro Vinícius Dos Santos Cabreira and Octavio Luiz Franco
Affiliation:
Keywords: Antimicrobial activity, Toxin, Disease control, Mechanism of action, Peptides, Unusual activity.
Abstract: The emergence of bacterial resistance to conventional antibiotics has been become a major issue in the health system. Currently, studies are being performed to develop new drugs that can replace conventional antibiotics. These new drugs include the antimicrobial peptides (AMPs), a heterogeneous group of molecules produced in a variety of bacterial, invertebrate, plant and animal species, which can serve as a nonspecific defense system that complements the highly specific cell-mediated immune response. AMPs have antimicrobial activities against a wide range of microorganisms, including bacteria, fungi, and viruses, and they are effective against pathogenic organisms that are resistant to common drugs. The most common mechanism of action of antibacterial peptides on microbial cells has been characterized as an alteration in the cellular membrane permeability. In contrast, there are AMPs with unusual strategies associated with cell wall and protein synthesis inhibition, nucleic acid binding or inactivation of toxins that enable microbial infection. Many pathogens can develop resistance strategies, inactivating or repelling AMPs through modification of the surface expression of pumps or secretion of proteases. In summary, this review focus on AMPs with non-conventional modes of actions and the microbial counter measures to resist these peptides.
Export Options
About this article
Cite this article as:
Machado dos Santos Leandro, Carvalho Vilas Boas de Esther, Silva de Affonseca e Flávia Varela, Cabreira Vinícius Dos Santos Pedro and Franco Luiz Octavio, Elucidating Unusual Modes of Action and Resistance of Antibacterial Peptides, Current Topics in Medicinal Chemistry 2017; 17 (5) . https://dx.doi.org/10.2174/1568026616666160713123203
DOI https://dx.doi.org/10.2174/1568026616666160713123203 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Minocycline: Neuroprotective Mechanisms in Parkinsons Disease
Current Pharmaceutical Design Pathologic Findings of Autoimmune Pancreatitis and IgG4-Related Disease
Current Immunology Reviews (Discontinued) Ascorbic Acid and Gene Expression: Another Example of Regulation of Gene Expression by Small Molecules?
Current Genomics Nutrition and Nutritional Management of Crohns Disease in Children and Adolescents
Current Nutrition & Food Science Melatonin Leads to Axonal Regeneration, Reduction in Oxidative Stress, and Improved Functional Recovery Following Sciatic Nerve Injury
Current Neurovascular Research Targeting the Bombesin/Gastrin-Releasing Peptide Receptor to Treat Sepsis
Recent Patents on Anti-Infective Drug Discovery The Role of Intestinal Microbiota in Graft versus Host Disease
Mini-Reviews in Medicinal Chemistry Anti-Interleukin-6 Receptor Antibody Treatment in Inflammatory Autoimmune Diseases
Reviews on Recent Clinical Trials The Immune Function of Ly6Chi Inflammatory Monocytes During Infection and Inflammation
Current Molecular Medicine Resisting the Sun with Vitamin D
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Design, Synthesis and Pharmacological Evaluation of Gastro- Protective Anti-inflammatory Analgesic Agents based on Dual Oxidative Stress / Cyclooxygenase Inhibition
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Effectiveness of Hsp90 Inhibitors as Anti-Cancer Drugs
Mini-Reviews in Medicinal Chemistry Immunosuppressive Therapies in Solid Organ Transplantation
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Surface-Active Helices in Transmembrane Proteins
Current Protein & Peptide Science Glia as a Turning Point in the Therapeutic Strategy of Parkinsons Disease
CNS & Neurological Disorders - Drug Targets Bioactive Bacterial Components: Could they Change the Probiotic World?
Current Bioactive Compounds Apoptosis and Efferocytosis in Mouse Models of Atherosclerosis
Current Drug Targets The Applications of Targeting Anti-Cancer Agents in Cancer Therapeutics
Anti-Cancer Agents in Medicinal Chemistry Treatment for Radiation-Induced Pulmonary Late Effects: Spoiled for Choice or Looking in the Wrong Direction?
Current Drug Targets Lipid Nanoparticles to Deliver miRNA in Cancer
Current Pharmaceutical Biotechnology