Inflammation and its treatment has been studied for thousands of years and is characterized
as a nonspecific but beneficial response of tissues to injury. Inflammation is distinguished by
symptoms such as redness, pain, and swelling. The anti-inflammatory agents are used to encounter
inflammation. It has been found that conventional synthetic nonsteroidal anti-inflammatory drugs
(NSAIDs) are effective in various inflammatory conditions but associated with gastrointestinal, liver
and kidney problems. Therefore, natural products could be an ideal therapeutic alternative. Our review
encounters all the alkaloids with anti-inflammatory effect and/or possible mechanism where reported.
It is concluded that further detail mechanistic and clinical studies could lead to the discovery
of more effective therapeutic agents in the class.