Microwave Assisted Synthesis and Antimicrobial Activity Evaluation of New Heterofunctionalized Norfloxacine Derivatives

Author(s): Meltem Mentese, Serpil Demirci, Serap B. Ozdemir, Ahmet Demirbas, Serdar Ulker, Neslihan Demirbas

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 10 , 2016

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Abstract:

The synthesis of new hybrid compounds containing several heterocyclic groups namely norfloxacine, 1,2,4-triazole, 1,3,4-oxadiazole, piperazine, morpholine, thiomorpholine, 1,3,4- thiadiazole etc. was performed by conventional and successfully optimized microwave assisted techniques. The effect of acid catalyst on one pot tricomponent Mannich reaction was investigated as well. The structures of newly synthesized compounds were eluciated on the basis of spectroscopic techniques. Also, the synthesized compounds were screened for their antimicrobial activities and most of them were found to possess good-moderate antimicrobial activity.

Keywords: Antimicrobial activity, mannich reaction, norfloxacine, piperazine, 1, 2, 4-triazole.

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Article Details

VOLUME: 13
ISSUE: 10
Year: 2016
Page: [1076 - 1090]
Pages: 15
DOI: 10.2174/1570180813666160712222922
Price: $65

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