A series of nineteen 2-aryl-4H-chromen-4-one derivatives 2a-2s were synthesized and
evaluated for their antiviral activity against Chikungunya virus (LR2006_OPY1) in Vero cell culture
by CPE reduction assay. Three compounds 2a, 2b and 2g, were found to be active at concentration of
(IC50) 0.44 M, 0.45 M and 2.02 M, respectively. Compounds having heterocyclic ring 2a and 2b
at the 2nd position of the chromenone were found to be potent inhibitor of ChikV. Cytotoxicity studies
were performed using Vero cell culture, compounds 2a and 2b exhibited SI of >100. Molecular
docking simulation has been carried out to understand the possible mechanism of action.
Keywords: 2-aryl-4H-chromen-4-one derivatives against chikungunya virus (ChikV). CPE reduction assay, Cell viability
assays, molecular docking studies.
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