Reverse Pharmacognosy and Reverse Pharmacology; Two Closely Related Approaches for Drug Discovery Development

Author(s): Soodabeh Saeidnia, Ahmad R. Gohari, Azadeh Manayi.

Journal Name: Current Pharmaceutical Biotechnology

Volume 17 , Issue 11 , 2016

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Abstract:

Pharmacognosy is a science, which study natural products as a source of new drug leads and effective drug development. Rational and economic search for novel lead structures could maximize the speed of drug discovery by using powerful high technology methods. Reverse pharmacognosy, a complementary to pharmacognosy, couples the high throughput screening (HTS), virtual screening and databases along with the knowledge of traditional medicines. These strategies lead to identification of numerous in vitro active and selective hits enhancing the speed of drug discovery from natural sources. Besides, reverse pharmacology is a target base drug discovery approach; in the first step, a hypothesis is made that the alteration of specific protein activity will produce beneficial curative effects. Both, reverse pharmacognosy and reverse pharmacology take advantages of high technology methods to accomplish their particular purposes. Moreover, reverse pharmacognosy effectively utilize traditional medicines and natural products as promising sources to provide new drug leads as well as promote the rational use of them by using valuable information like protein structure databases and chemical libraries which prepare pharmacological profile of traditional medicine, plant extract or natural compounds.

Keywords: Drug discovery, in silico, natural products, reverse pharmacognosy, reverse pharmacology, traditional medicine.

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Article Details

VOLUME: 17
ISSUE: 11
Year: 2016
Page: [1016 - 1022]
Pages: 7
DOI: 10.2174/1389201017666160709200208
Price: $65

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