Emerging Role for RBM20 and its Splicing Substrates in Cardiac Function and Heart Failure

Author(s): Jipeng Ma, Linhe Lu, Wei Guo, Jun Ren, Jian Yang

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 31 , 2016

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Heart failure is one of the devastating public health problems with high mortality. Among various contributing factors for heart failure, severe dilated cardiomyopathy is the most common indication for cardiac transplantation. Recent evidence revealed that RBM20 mutation represents one main cause for familial dilated cardiomyopathy with a 3% prevalence in all forms of dilated cardiomyopathy. Further scrutiny of molecular mechanisms suggests a role for RBM20 as a functional splicing factor for protein isoform transition, indicating the clinical value of RBM20 mutations in the diagnosis and treatment of heart diseases. RBM20 alternatively splices a set of genes including titin, CaMKIID, and GIT2 at the post transcriptional level to yield diverse isoforms. These target proteins are necessary for cardiac homeostasis including structure and signal transduction. Mutations in RBM20 cause dilated cardiomyopathy along with dysregulated isoform switch. This review aims to summarize the current knowledge of RBM20-related dilated cardiomyopathy and heart failure as well as the underlying mechanism. We will emphasize and thoroughly discuss two splicing targets including titin and CaMKII which are known to play a vital role in dilated cardiomyopathy and heart failure.

Keywords: RBM20, heart failure, dilated cardiomyopathy, alternative splicing, titin, CaMKII.

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Article Details

Year: 2016
Published on: 01 July, 2016
Page: [4744 - 4751]
Pages: 8
DOI: 10.2174/1381612822666160701145322
Price: $65

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