In this study, we want to have an extensive overview on the application of
triphosgene in organic synthesis. We begin with an introductory discussion of the nature of
triphosgene, and introduce several procedures for the preparation of triphosgene. It holds an
advantage over other similar reagents, such as phosgene and diphosgene, of being a safe and
easy to handle solid. On the other hand, it is safer and more convenient to transport and
store. Exact amounts may be weighed easily and used to perform desired chemical transformations
and reaction requires only one-third equivalent of triphosgene in most cases. We
then survey the reactions and transformations that performed using triphosgene. The reactions
have been performed using triphosgene are carried out under mild conditions and afford
good to excellent yields. The use of triphosgene as a synthetic auxiliary in the preparation
of many important classes of organic compounds has been investigated intensively in the last years. Finally,
we summarize the advantages of triphosgene in organic synthesis.
Keywords: Triphosgene, crystalline solid, organic synthesis, phosgene, economical, mild conditions.
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