Methicillin-Resistant Staphylococcus aureus (MRSA) is a Gram-positive bacterium
which causes community and hospital-acquired infections. Synthetic drug/antibiotic
treatment for MRSA-related infections is becoming less effective and natural products may
be an emerging new alternative for future antibacterial drug development. Alkaloids are a
class of natural compounds which are known for their phytochemistry and pharmacology.
This review focuses on 32 alkaloids isolated from various plants that showed marked antibacterial
activity against MRSA by acting through different mechanisms such as inhibition
of pyruvate kinase, Quorum quenching effect, alteration in efflux pump in MRSA and intercalating
of bacterial DNA, to name just a few. In addition, the use of recent plant alkaloids
against clinical isolates of MRSA has also been discussed.
Keywords: Alkaloids, MRSA, different susceptibility mechanisms.
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