The full success of pharmacological therapies is strongly depending on the use of suitable,
efficient and smart drug delivery systems (DDSs). Thus DDSs development is one of the main challenges
in pharmaceutical industry both to achieve tailored carrier systems based on drug features and to
promote manufacturing innovations to reduce energetic resources, emissions, wastes and risks. Main
functions of an ideal DDS are: to protect loaded active molecules from degradation in physiological environments;
to deliver them in a controlled manner and towards specific organs or tissues, to allow the
maintenance of drug concentration within therapeutic window. Smart features, such as those able to induce
active molecule release upon the occurrence of specific physiological stimuli, are also desirable.
Under the manufacturing point of view, the current industrial scenery is obliged to respond to the increasing
market requirements and to the mandatory rules in sustainable productions such as raw material
and energy savings.
In this work a general framework on drug delivery systems preparation techniques is presented. In particular
two sections on innovation in preparative approaches carried out are detailed. These latter involve
the use of microwave and ultrasonic energy applied in the production of polymeric and lipidic delivery
systems on micro- and nanometric scale. The novelties of these preparative approaches are emphasized
and examples of developed drug delivery carriers, loaded with vitamins and drug mimicking
siRNA, are shown.