Dual Nuclear/Fluorescence Imaging Potantial of Zinc(II) Phthalocyanine in MIA PaCa-2 Cell Line

Author(s): Fatma Yurt Lambrecht, Mine Ince, Ozge Er, Kasim Ocakoglu, Fatma Aslıhan Sarı, Cagla Kayabasi, Cumhur Gunduz

Journal Name: Current Radiopharmaceuticals

Volume 9 , Issue 3 , 2016


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Abstract:

Background and Objective: Pancreatic cancer is very common and difficult to diagnose in early stage. Imaging systems for diagnosing cancer have many disadvantages. However, combining different imaging modalities offers synergistic advantages. Optical imaging is the most multidirectional and widely used imaging modality in both clinical practice and research.

Methods: In present study, Zinc(II) phthalocyanine [Zn(II)Pc] was synthesized, labeled with iodine- 131 and in vitro study was carried out. The intracellular uptake studies of radiolabeled Zn(II)Pc were performed in WI-38 [ATCC CCL-75™, tissue: human fibroblast lung] and MIA PaCa-2 [ATCC CRL-1420™, tissue: human epithelial pancreas carcinoma] cell lines.

Results: The intracellular uptake efficiency of radiolabeled Zn(II)Pc in MIA PaCa-2 cells was determined two times higher than WI-38 cells. Also, fluorescence imaging (FI) efficiency of synthesized Zn(II)Pc was investigated in MIA PaCa-2 cells and significant uptake was observed.

Conclusion: Zn(II)Pc might be used as a new agent for dual fluorescence/nuclear imaging for pancreatic cancer.

Keywords: 131I, fluorescence imaging, nuclear imaging, MRI, Pancreatic cancer, Zinc(II) Phthalocyanine.

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2016
Published on: 11 December, 2016
Page: [222 - 227]
Pages: 6
DOI: 10.2174/1874471009666160628083416
Price: $65

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