Background and Objective: Pancreatic cancer is very common and difficult to diagnose
in early stage. Imaging systems for diagnosing cancer have many disadvantages. However,
combining different imaging modalities offers synergistic advantages. Optical imaging is the most
multidirectional and widely used imaging modality in both clinical practice and research.
Methods: In present study, Zinc(II) phthalocyanine [Zn(II)Pc] was synthesized, labeled with iodine-
131 and in vitro study was carried out. The intracellular uptake studies of radiolabeled Zn(II)Pc were
performed in WI-38 [ATCC CCL-75™, tissue: human fibroblast lung] and MIA PaCa-2 [ATCC
CRL-1420™, tissue: human epithelial pancreas carcinoma] cell lines.
Results: The intracellular uptake efficiency of radiolabeled Zn(II)Pc in MIA PaCa-2 cells was
determined two times higher than WI-38 cells. Also, fluorescence imaging (FI) efficiency of
synthesized Zn(II)Pc was investigated in MIA PaCa-2 cells and significant uptake was observed.
Conclusion: Zn(II)Pc might be used as a new agent for dual fluorescence/nuclear imaging for