(R)-Ricinoleic acid (RA) [(12R,9Z)-hydroxyoctadecenoic acid],
the main compound of castor seed oil, because of its unusual structure readily
undergoes multi-directional chemical and biochemical transformations to
produce derivatives with the retained carbon skeleton or with its degradation.
Many of these are of high biological activity, as documented by an in vitro
study, and possess therapeutic potential. This review article provides an
overview of the recent developments in the area of synthesis of RA based
compounds with anticancer and antimicrobial activities. Moreover, the antiinflammatory
and analgesic properties of some ricinoleic acid derivatives are
Keywords: Ricinoleic acid, castor oil, derivatives, biological activity, antimicrobial activity, antiproliferative activity,
Ricinus communis, polyesters, bioactive polymers.
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