Title:The Multiple Roles of XBP1 in Regulation of Glucose and Lipid Metabolism
VOLUME: 18 ISSUE: 6
Author(s):Jianjing Yang, Xiaojie Wu, Xiaoting Wu, Dijia Zhou, Tengmei Lin, Saidan Ding, Yu Zhang, Jiangnan Xue* and Qichuan Zhuge*
Affiliation:Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, Department of Immunology, Binzhou Medical University, Yantai, Department of Operating Theatre, Binzhou People`s Hospital, Binzhou, Department of Immunology, Binzhou Medical University, Yantai, Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, Department of Immunology, Binzhou Medical University, Yantai, Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000
Keywords:Metabolic regulator/housekeeper, XBP1, PI3K, ER stress, IRE1α, insulin.
Abstract:X-box binding protein1 (XBP1) especially exerts its fundamental effects in the cellular organelle
endoplasmic reticulum (ER) via affecting three trans-membrane stress sensor proteins: PKRlike
ER kinase (PERK), inositol-requiring enzyme 1(IRE1) and activating transcription factor
6(ATF6). At the center of XBP1’s broad effects is its remarkable metabolic housekeeper function.
XBP1 decreased glucose dysfunction via funneling its effects on improving insulin sensitivity and
stimulating insulin secretion. However, XBP1 also yields its double-edged effects, driving the transformation
from excess glucose to lipid, which is a key contribution to obesity and T2DM. In this review,
we highlight the vital mechanism of XBP1 in manipulating glucose and lipid metabolism involved
by multiple signaling pathways.
