L-Arginine Modulates Glucose and Lipid Metabolism in Obesity and Diabetes

Author(s): Shengdi Hu, Meng Han, Arash Rezaei, Defa Li, Guoyao Wu*, Xi Ma*

Journal Name: Current Protein & Peptide Science

Volume 18 , Issue 6 , 2017

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Graphical Abstract:


Type 2 diabetes has become a global public health problem affecting approximately 380 million people throughout the world. It can cause many complications and lead to greater mortality. At present, there is no available medicine for effectively preventing diabetes. L-arginine, a functional amino acid, the precursor of nitric oxide, plays a crucial role in maintenance, reproduction, growth, anti-aging and immunity for animals. Growing clinical evidence indicates that dietary L-arginine supplementation can reduce obesity, decrease arterial blood pressure, resist oxidation and normalize endothelial dysfunction to bring about remission of type 2 diabetes. The potential molecular mechanism may play a role in modulating glucose homeostasis, promoting lipolysis, maintaining hormone levels, ameliorating insulin resistance, and fetal programing in early stages. The possible signaling pathway of the beneficial effects of L-arginine likely involves L-arginine-nitric oxide pathway through which cell signal protein can be activated. Accumulating studies have indicated that L-arginine may have potential to prevent and/or relieve type 2 diabetes via restoring insulin sensitivity in vivo.

Keywords: L-arginine, diabetes, nitric oxide, glucose/lipid metabolism, insulin-resistance.

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Article Details

Year: 2017
Page: [599 - 608]
Pages: 10
DOI: 10.2174/1389203717666160627074017
Price: $65

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