Spirooxindoles as Potential Pharmacophores

Author(s): Siva S. Panda*, Rachel A. Jones, Praveen Bachawala, Prabhu P. Mohapatra

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 17 , Issue 16 , 2017

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Abstract:

Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.

Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.

This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.

Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.

Keywords: Biological importance, chemistry, heterocycles, pharmacophores, spirooxindoles, synthesis.

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Article Details

VOLUME: 17
ISSUE: 16
Year: 2017
Page: [1515 - 1536]
Pages: 22
DOI: 10.2174/1389557516666160624125108
Price: $65

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