Nowadays, the stereoselective synthesis of naturally occurring compounds showing biological activity
has attracted much attention and stirred up the interest of organic synthetic chemists. Apparently, the multi-step
total synthesis of such complex molecules bearing several stereogenic centers demands the development of the
efficient and operational strategies for the induction of chirality in a certain step (steps). Among the most practical
approaches in the area of stoichiometric asymmetric synthesis, the SAMP/RAMP hydrazone methodology has
been found to be a powerful tool in the synthesis of numerous naturally occurring, and bioactive compounds. In
this report, we try to highlight the applications of this methodology in asymmetric synthesis.
In memory of Professor Abbas Shafiee (1937-2016) who trusted me a while ago on a project led to the production
of Codeine Phosphate in Iran.