The labeling of biomolecule using 99mTc-tricarbonyl is an interesting tool for the
diagnosis of diseases. This labeling startegy has several advantages as compared to other
common radiolabeling techniques. This review is a complete overview of synthesis and
chemistry of 99mTc-tricarbonyl molecule for labeling peptides and proteins. Also, the effect
of ligand type on the stability and in vivo biodistribution of 99mTc-tricarbonyl labeled biomolecules
are discussed. Chemistries of cyclopentadienyl and hexa histidine tag as two important
bifunctional chelating agents (BFCA) are presented. The in vitro and in vivo behaviors
of some 99mTc-tricarbonyl labeled peptides and proteins are explained. Preclinical outcomes
revealed that these labeled compounds are biologically, kinetically and thermodynamically
stable. Findings showed that 99mTc-tricarbonyl labeled biomolecules are promising
tools for future clinical applications in image diagnosis.
Keywords: Tricarbonyl, 99mTc, peptide, labeling.
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