A number of thiophen-2(5H)-ones with different substituents in the 3-, 4-
and 5-position have been synthesized and tested as inhibitors of biofilm production
by the marine bacterium Vibrio harveyi BB120. Concentrations that inhibited 50%
or 90% of biofilm formation (BIC50, BIC90) and of plantonic growth (PIC50, PIC90)
Keywords: 5-alkylidenethiophen-2(5H)-ones, biofilm inhibition, quorum sensing, synthesis.
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