Rexinoids for Prevention and Treatment of Cancer: Opportunities and Challenges

Author(s): Karen T. Liby, Michael B. Sporn

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 6 , 2017

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Graphical Abstract:


Rexinoids are selective ligands for the nuclear receptors known as RXRs. They do not bind to the receptors for all-trans-retinoic acid (RARs). Many new rexinoids have been synthesized and then assayed for their ability to suppress proliferation of cancer cells, to inhibit activation of inflammatory cells of the tumor microenvironment, and to prevent carcinogenesis in animal models relevant to human disease. Here we review the literature on the effects of 4 such rexinoids: bexarotene, LG100268, LG101506, and NRX194204. These rexinoids also have potent synergistic effects when used in combination with other active pharmacological agents, and practical clinical applications would benefit from these actions.

Keywords: RXR, Bexarotene, LG100268, Inflammation, Carcinogenesis, Combination therapy.

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Article Details

Year: 2017
Page: [721 - 730]
Pages: 10
DOI: 10.2174/1568026616666160617090702
Price: $65

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PDF: 40