Title:Role of Stromal-Derived Factor-1 in Mesenchymal Stem Cell Paracrinemediated Tissue Repair
VOLUME: 11 ISSUE: 7
Author(s):Qing Luo, Bingyu Zhang, Dongdong Kuang and Guanbin Song
Affiliation:College of Bioengineering, Chongqing University, Chongqing 400044, People’s Republic of China.
Keywords:Mesenchymal stem cells, paracrine, stromal-derived factor-1, tissue repair.
Abstract:In addition to the multi-lineage differentiation potential of mesenchymal
stem cells (MSCs), studies in recent years have focused on the role of MSC paracrine
in tissue regeneration. Due to their paracrine effects in damaged tissues, MSCs may
be a promising therapeutic cell type in the treatment of many disorders. However, the
mechanisms underlying the effects of MSC paracrine on tissue regeneration remain
largely unknown, which limits the development of therapeutic applications. Stromalderived
factor-1 (SDF-1) has been demonstrated to be a crucial factor that supports
tissue regeneration. MSCs and damaged tissues are the main sources of SDF-1 in the
regenerative microenvironment. In MSC paracrine-mediated tissue repair, SDF-1 not
only acts as an important MSC-derived paracrine factor that facilitates wound healing
but also improves the efficiency of MSC paracrine. In this review, we first outline the sources and regulators
of SDF-1 in the regenerative microenvironment. We then summarize and discuss the current understanding
of the roles of SDF-1 in MSC paracrine-mediated tissue repair, as well as its underlying mechanisms
of action. Illustrating the role of SDF-1 in MSC paracrine-mediated tissue repair will facilitate a
comprehensive understanding of MSC paracrine and will aid in the development of strategies to enhance
the efficiency of therapies involving transplanted MSCs.
