Curcumin is one of the principle bioactive compounds used in the ayurvedic
medicine system that has the history of over 5000 years for human use. Curcumin an “Indian
Gold” is used to treat simple ailments like the common cold to severe life threatening diseases
like cancer, and HIV.
Though its contribution is immense for the health protection and disease prevention, its
clinical use is limited due to its susceptible nature to alkaline pH, high temperature, presence
of oxygen and light. Hence it becomes extremely difficult to maintain its bioactivity during
processing, storage and consumption.
Recent advancements in the application of nanotechnology to curcumin offer an opportunity
to enhance its stability, bioactivity and to overcome its pharmacokinetic mismatch. This in
turn helps to bridge the gaps that exist between its bench top research data to its clinical
Among the various types of nano/micro delivery systems, lipid based delivery systems are well studied and are
the best suited delivery systems to enhance the stability and pharmacokinetic profile of curcumin both for pharma
and the food application.
In the current review, effort will be made to recapitulate the work done in the past to use lipid based delivery
systems (liposomes, solid lipid nanoparticles, and emulsions) to enhance the application of curcumin for health
promotion and disease prevention. Further, future prospects for the utilization of these lipid-based delivery systems
will be discussed in detail.