Dietary Supplementation of Curcumin Alleviates NF-κB-dependent Skeletal Muscle Wasting in Rat

Title:Dietary Supplementation of Curcumin Alleviates NF-κB-dependent Skeletal Muscle Wasting in Rat

Volume: 16 Issue: 2

Author(s): Jun He, Hongmei Xie and Shan Wu

Affiliation:

Keywords: Curcumin, inflammation, muscle wasting, nutrition, regulation, rat.

Abstract: Background: Activation of the nuclear factor-kappa β (NF-κB) signaling results in releasing of a variety of inflammatory cytokines that can induce skeletal muscle wasting (MW) in mammals. Curcumin is a natural product from spice turmeric that can block biological events in which NF-κB plays a critical role.

Objective: The present study was conducted to evaluate the beneficial effects of curcumin on the NF-κB-dependent MW in rats.

Methods: The MW rats were induced by lipopolysaccharide (LPS) injection and rats were fed 15 g curcumin per kg diet for 16 d.

Results: LPS not only decreased the growth performance of rat, but significantly elevated its serum IL-1 concentration and muscle proteolysis rate. Interestingly, curcumin significantly prevented the muscle proteolysis rate and down-regulated expression levels of two critical muscle-specific ubiquitin ligases (Atrogin-1 and MuRF-1). When muscles from MW rats were incubated with curcumin in vitro, the calpain-, cathepsin L-, and proteasome-dependent muscle proteolysis were significantly decreased. Moreover, the nuclear NF-κB/p65 protein abundance were also decreased by curcumin.

Conclusion: The results not only suggest a molecular mechanism by which curcumin modulates the inflammatory responses, but also offer a feasible avenue to ameliorate the NF-κB-dependent muscle proteolysis.

Cite this article as:

He Jun, Xie Hongmei and Wu Shan, Dietary Supplementation of Curcumin Alleviates NF-κB-dependent Skeletal Muscle Wasting in Rat, Endocrine, Metabolic & Immune Disorders - Drug Targets 2016; 16 (2) . https://dx.doi.org/10.2174/1871530316666160613115221