Background: The Present work describe the synthetic protocol of a new series of 2-(4-(2-(5-
Ethylpyridin-2-yl)ethoxy)phenyl)-4-(4-substituted)-2,3-dihydrobenzo [b][1,4]thiazepine (5a-j) by the
cyclization of chalcones (4a-j) with 2-amino thiophenol by microwave induced solvent free conditions
as well as conventional approach.
Methods: The elemental analysis and spectral method (IR, 1H and 13C NMR) were characterized the
structure of all synthesized compounds.
Result: These compounds were screened for antibacterial and antifungal activity. Bezothiazepine derivative 5f showed
potency (MBC = 50 µg/ml) against gram negative P. aeruginosa and 5i displyed encouraging activity (MFC = 200 µg/ml)
against A. niger and A. clavatus.
Conclusion: The solvent less non-conventional microwave induced synthesis of compound (5a-j) has been proven considerable
advantageous over conventional methods.