Microwave Assisted Synthetic Approach of New Pyridine based Benzothiazepines: Their Antibacterial and Antifungal Activities

Author(s): Navin B. Patel, Hemant R. Patel, Faiyazalam M. Shaikh, Dhanji P. Rajani, Vatsal M. Patel

Journal Name: Current Microwave Chemistry

Volume 3 , Issue 3 , 2016

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Background: The Present work describe the synthetic protocol of a new series of 2-(4-(2-(5- Ethylpyridin-2-yl)ethoxy)phenyl)-4-(4-substituted)-2,3-dihydrobenzo [b][1,4]thiazepine (5a-j) by the cyclization of chalcones (4a-j) with 2-amino thiophenol by microwave induced solvent free conditions as well as conventional approach.

Methods: The elemental analysis and spectral method (IR, 1H and 13C NMR) were characterized the structure of all synthesized compounds.

Result: These compounds were screened for antibacterial and antifungal activity. Bezothiazepine derivative 5f showed potency (MBC = 50 µg/ml) against gram negative P. aeruginosa and 5i displyed encouraging activity (MFC = 200 µg/ml) against A. niger and A. clavatus.

Conclusion: The solvent less non-conventional microwave induced synthesis of compound (5a-j) has been proven considerable advantageous over conventional methods.

Keywords: Antibacterial, antifungal, benzothiazepine, chalcone, microwave, solvent-free.

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Article Details

Year: 2016
Published on: 19 July, 2016
Page: [212 - 218]
Pages: 7
DOI: 10.2174/2213335603666160609123550
Price: $25

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