Background: Despite the significant developments made in the field of diagnosis
and treatment modalities of cancer during the last two decades, it still remains one of the
most life threatening diseases killing 8.2 million people annually across the globe. It has
been well-established that development of chemoresistance in cancer cells is the major cause
of failure of chemotherapeutic agents in clinic. Most of the chemotherapeutic agents currently
being used activate NF-κB and NF-κB regulated gene products in cancer cells and
induce drug resistance. Increasing lines of evidences suggest that NF-κB blockers have high
potential in decreasing drug resistance and sensitize cancer cells to chemotherapeutic agents.
Methods: A through literature search was carried out in pubmed to identify natural NF-κB
inhibitors that possess high potential in sensitizing cancer cells.
Results: Our literature search retrived a number of NF-κB inhibitors that have been identified
during the last several years. Notably, the inhibitors obtained from Mother Nature such
as curcumin, tocotrienol, resveratrol, garcinol etc. are found to be highly safe, efficacious and inexpensive. Many
preclinical and clinical studies have revealed that these agents can block the activation of NF-κB in cancer cells to
overcome drug resistance and make them sensitive to chemotherapeutic agents.
Conclusion: Both basic and clinical research revealed that constitutive activation of NF-κB is the prime reason
for inducing drug resistance in cancer cells. This comprehensive review scientifically evaluates the chemosensitizing
potential of these natural agents which serve as potent NF-κB blockers, based on evidence based literature.