The ever increasing cases of microbial resistance pose a major threat to
the scientific community and therefore the need for discovery and development of
newer antimicrobial agents with novel mode of action is becoming critical. One of
the ways to tackle this herculean problem is to generate hybrid molecules by
combining two or more bioactive heterocyclic moieties in a single molecular
platform. The review here describes published results of our research group’s
endeavors towards development of potential new and safe antimicrobial agents with
better effectiveness by using the hybrid approach. In the present review article the
landscaping of heterocycles like 4-thiazolidinones, benzimidazole and quinoline are
described. Compounds displaying two of more fold antimicrobial activity are
included in the review.
Keywords: Antimicrobial agents, benzimidazole, bioactive heterocycles, hybrid molecules, 4-thiazolidinone, quinoline.
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