Background: In the past few decades, the applications of nanotechnology to improve
visual health and patient´s life quality have been improving. The nanoscience, introduced
molecules of 100 nm in size offering alternatives to significantly improve the penetration
on the ocular barriers and achieve better results on the delivery and biocompatibility of
drugs inside the ocular globe.
Objective: To conduct a systematic review on nanotechnology using ocular pharmacology in
order to improve patient’s quality life.
Method: The review was undertaken in Science Direct, Scopus, Elsevier, using the keywords:
nanotechnology in ocular administration, ocular nanocarriers, and ocular nano drug products.
Results: In the recent decades, the most relevant innovation in nanotechnology is the implementation
of nano drug products to treat ocular infections, glaucoma, nonsteroidal antiinflammatory
drugs, diabetic retinopathy, macular degeneration associated with the age, drug
delivery forms to stop neovascularization, and the repair of corneal ulcers among others.
Conclusion: New drugs incorporating nanotechnology are useful to enhance the penetration
into the visual barriers and allow better effect of drugs. Multiple ocular disorders such as retinopathy,
corneal neovascularization’s, and glaucoma, can be treated with nanotechnology
prodrugs; which have better mechanisms of action and are less toxic for the ocular tissues.
These new drugs are known as nanoengineered drug delivery systems (nDDS) and the supersaturated
self-nano emulsifying drug delivery systems (S-SNEDDS). They are useful to improve
the bioavailability and the control of the active principles of ophthalmic solutions
which are released on the tissues and allow better penetration towards the posterior segment.