Contextualizing Genetics for Regional Heart Failure Care

Author(s): Pupalan Iyngkaran, Merlin C. Thomas, Renee Johnson, John French, Marcus Ilton, Peter McDonald, David L. Hare, Diane Fatkin

Journal Name: Current Cardiology Reviews

Volume 12 , Issue 3 , 2016

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Graphical Abstract:


Congestive heart failure (CHF) is a chronic and often devastating cardiovascular disorder with no cure. There has been much advancement in the last two decades that has seen improvements in morbidity and mortality. Clinicians have also noted variations in the responses to therapies. More detailed observations also point to clusters of diseases, phenotypic groupings, unusual severity and the rates at which CHF occurs. Medical genetics is playing an increasingly important role in answering some of these observations. This developing field in many respects provides more information than is currently clinically applicable. This includes making sense of the established single gene mutations or uncommon private mutations. In this thematic series which discusses the many factors that could be relevant for CHF care, once established treatments are available in the communities; this section addresses a contextual role for medical genetics.

Keywords: Congestive heart failure, genetics, indigenous australian, polymorphism, review, therapeutics.

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Article Details

Year: 2016
Page: [231 - 242]
Pages: 12
DOI: 10.2174/1573403X12666160606123103
Price: $65

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PDF: 34
PRC: 2