Background: Spice and spice-derived compounds have been identified and explored
for their health benefits since centuries. One of the spice long pepper has been traditionally
used to treat chronic bronchitis, asthma, constipation, gonorrhea, paralysis of the
tongue, diarrhea, cholera, malaria, viral hepatitis, respiratory infections, stomach ache, diseases
of the spleen, cough, and tumors. Methods: In this review, the evidences for the chemopreventive
and chemotherapeutic potential of piperlongumine have been described.
Results: The active component piperlonguime has shown effective against various ailments
including cancer, neurogenerative disease, arthritis, melanogenesis, lupus nephritis, and
hyperlipidemic. These beneficial effects of piperlongumine is attributed to its ability to
modulate several signaling molecules like reactive oxygen species, kinases, proteasome,
proto-oncogenes, transcription factors, cell cycle, inflammatory molecules and cell growth
and survival molecules. Piperlongumine also chemosensitizes to drugs resistant cancer cells.
Conclusion: Overall the consumption of long peppers is therefore recommended for the prevention and treatment
of various diseases including cancer, and thus piperlongumine may be a promising future candidate drug against