Indole is a potential lead for drug design which has been found in numerous pharmaceutically
important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus
and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation
to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy.
Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest
among scientists. This review describes the synthesis, bioactivities and SARs of indole-based
agents targeting tubulin polymerization during the past decade.