Cardiovascular diseases are the leading cause of death globally with limited treatment
options. Despite improved pharmacological therapy, scientific understandings on the root mechanisms
of cardiovascular diseases are still not fully understood. It is well known that inflammation
plays a key role in the pathogenesis of cardiovascular diseases and controlling this inflammatory
pathway may inhibit the progression of this chronic disease. Protein Kinase R (PKR), a serine
threonine kinase is activated during various pathological conditions. Activation of PKR can induce
apoptosis, inflammation and oxidative stress. Since PKR has multidimensional roles, thus PKR is an
attractive target for treating cardiovascular and metabolic disorders. The goal of this review is to
discuss potential role of PKR in cardiovascular diseases, pathways activated by it and association
between pathways activated.
Keywords: PKR, cardiovascular disease, inflammation.
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