The Role of PKR as a Potential Target for Treating Cardiovascular Diseases

Author(s): Arti Dhar

Journal Name: Current Cardiology Reviews

Volume 13 , Issue 1 , 2017

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Graphical Abstract:


Cardiovascular diseases are the leading cause of death globally with limited treatment options. Despite improved pharmacological therapy, scientific understandings on the root mechanisms of cardiovascular diseases are still not fully understood. It is well known that inflammation plays a key role in the pathogenesis of cardiovascular diseases and controlling this inflammatory pathway may inhibit the progression of this chronic disease. Protein Kinase R (PKR), a serine threonine kinase is activated during various pathological conditions. Activation of PKR can induce apoptosis, inflammation and oxidative stress. Since PKR has multidimensional roles, thus PKR is an attractive target for treating cardiovascular and metabolic disorders. The goal of this review is to discuss potential role of PKR in cardiovascular diseases, pathways activated by it and association between pathways activated.

Keywords: PKR, cardiovascular disease, inflammation.

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Article Details

Year: 2017
Published on: 26 May, 2016
Page: [28 - 31]
Pages: 4
DOI: 10.2174/1573403X12666160526122600
Price: $65

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PDF: 37