Marine Depsipeptides as Promising Pharmacotherapeutic Agents

Author(s): Marisa Rangel, Carlos José Correia de Santana, Andréia Pinheiro, Lilian dos Anjos, Tania Barth, Osmindo Rodrigues Pires Júnior, Wagner Fontes, Mariana S. Castro

Journal Name: Current Protein & Peptide Science

Volume 18 , Issue 1 , 2017

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Abstract:

Depsipeptides are a group of biologically active peptides that have at least one of the amide bonds replaced by an ester bond. These peptides sometimes present additional chemical modifications, including unusual amino acid residues in their structures. Depsipeptides are known to exhibit a large array of bioactivities, such as anticancer, antiproliferative, antimicrobial, antiviral and antiplasmodial properties. They are commonly found in marine organisms: bacteria, tunicates, mollusks, sponges, and others. Herein, we summarize the latest insights about marine depsipeptides, their mechanisms of action and potential as therapeutic agents.

Keywords: Bioactive, marine depsipeptides, mechanism of action, therapeutic agents.

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Article Details

VOLUME: 18
ISSUE: 1
Year: 2017
Page: [72 - 91]
Pages: 20
DOI: 10.2174/1389203717666160526122130
Price: $65

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