Depsipeptides are a group of biologically active peptides that have at
least one of the amide bonds replaced by an ester bond. These peptides sometimes
present additional chemical modifications, including unusual amino acid residues in
their structures. Depsipeptides are known to exhibit a large array of bioactivities,
such as anticancer, antiproliferative, antimicrobial, antiviral and antiplasmodial
properties. They are commonly found in marine organisms: bacteria, tunicates, mollusks,
sponges, and others. Herein, we summarize the latest insights about marine
depsipeptides, their mechanisms of action and potential as therapeutic agents.